Malignant Histiocytosis in A Cat : a Case Report

Malignant Histiocytosis in A Cat : a Case Report

P. Phurahong1*, P. Pensitiporn1, M. Samanukorn1, L. Ekthamasut1, R.Tantisak1, C. Wangdee2, W.Banlunara3

1Thonglor Pet Hospital, Bangkok 10310, Thailand
Department of Veterinary Surgery2, Department of Pathology3, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand

*Corresponding author: [email protected]

Keywords: Amputation, Cat, Histiocytic, Malignant histiocytosis, Neoplasia

Malignant histiocytosis (MH) is a neoplastic
proliferation of macrophages. The majority of this
tumors in cats was disseminated and characterized by
progressive and invasive multi-systemic neoplastic
proliferation of morphologically atypical histiocytes
and its precursors(5). The affected organs include
skin, liver, spleen, lymph nodes, and bone marrow.
This tumor has been rarely reported in cats. It
typically occurs in large-breed dogs especially
Bernese Mountain dogs, Golden Retrievers,
Rottweilers, and Flat-coated Retrievers. In cat, it can
occur individually at any age without sex or breed
predisposition. Marked lymphadenopathy,
hepatomegaly, splenomegaly, anemia and jaundice
are the most important clinical findings reported in
cats(5). A diagnosis of MH is made on the basis of
clinical signs, as well as clinicopathologic,
histopathologic, immuno-histochemical, and
immunophenotypic findings. Markers for histiocytic
cells are used to differentiate MH from epithelial and
lymphoid neoplasms(2). Only one report showed a
nine-year-old spayed female domestic shorthair cat
presenting MH with a skin lesion of the left tarsus
(4). The aim of this report was to describe diagnostic
method, treatment outcome and complication of
malignant histiocytosis in a cat.